Arthur Robertson Cushny
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Arthur Robertson Cushny FRS
FRSE Fellowship of the Royal Society of Edinburgh (FRSE) is an award granted to individuals that the Royal Society of Edinburgh, Scotland's national academy of science and letters, judged to be "eminently distinguished in their subject". This soci ...
LLD (6 March 1866 – 25 February 1926), was a Scottish pharmacologist and physiologist who became a Fellow of the Royal Society.


Life

Cushny was born on 6 March 1866 in
Fochabers Fochabers (; gd, Fachabair or Fothabair) is a village in the Parish of Bellie, in Moray, Scotland, east of the cathedral city of Elgin and located on the east bank of the River Spey. 1,728 people live in the village, which enjoys a rich mus ...
,
Moray Moray () gd, Moireibh or ') is one of the 32 local government council areas of Scotland. It lies in the north-east of the country, with a coastline on the Moray Firth, and borders the council areas of Aberdeenshire and Highland. Between 1975 ...
,
Scotland Scotland (, ) is a country that is part of the United Kingdom. Covering the northern third of the island of Great Britain, mainland Scotland has a border with England to the southeast and is otherwise surrounded by the Atlantic Ocean to the ...
, the fourth son of Rev John Cushny of Speymouth and his wife, Catherine Ogilvie Brown. He attended a local rural school until he enrolled at the
University of Aberdeen The University of Aberdeen ( sco, University o' 'Aiberdeen; abbreviated as ''Aberd.'' in List of post-nominal letters (United Kingdom), post-nominals; gd, Oilthigh Obar Dheathain) is a public university, public research university in Aberdeen, Sc ...
and received an
M.A. A Master of Arts ( la, Magister Artium or ''Artium Magister''; abbreviated MA, M.A., AM, or A.M.) is the holder of a master's degree awarded by universities in many countries. The degree is usually contrasted with that of Master of Science. Tho ...
in 1886. Then in 1889 he graduated from medical studies at
Marischal College Marischal College ( ) is a large granite building on Broad Street in the centre of Aberdeen in north-east Scotland, and since 2011 has acted as the headquarters of Aberdeen City Council. However, the building was constructed for and is on long- ...
,
Aberdeen Aberdeen (; sco, Aiberdeen ; gd, Obar Dheathain ; la, Aberdonia) is a city in North East Scotland, and is the third most populous city in the country. Aberdeen is one of Scotland's 32 local government council areas (as Aberdeen City), and ...
, receiving C.M., M.B. and
M.D. Doctor of Medicine (abbreviated M.D., from the Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a professional degree. T ...
degrees in 1892. Aroused by interests of physiological drug interaction, he traveled to the European continent and spent a year of associated study under Oswald Schmiedeberg at
Straßburg Strasbourg (, , ; german: Straßburg ; gsw, label=Bas Rhin Alsatian, Strossburi , gsw, label= Haut Rhin Alsatian, Strossburig ) is the prefecture and largest city of the Grand Est region of eastern France and the official seat of the Eu ...
,
German Empire The German Empire (),Herbert Tuttle wrote in September 1881 that the term "Reich" does not literally connote an empire as has been commonly assumed by English-speaking people. The term literally denotes an empire – particularly a hereditary ...
and six months in
Berne german: Berner(in)french: Bernois(e) it, bernese , neighboring_municipalities = Bremgarten bei Bern, Frauenkappelen, Ittigen, Kirchlindach, Köniz, Mühleberg, Muri bei Bern, Neuenegg, Ostermundigen, Wohlen bei Bern, Zollikofen , website ...
under
Hugo Kronecker Karl Hugo Kronecker (27 January 1839 – 6 June 1914) was a German physiologist from Liegnitz, Prussian Silesia. He was the brother of Leopold Kronecker. He studied medicine in Berlin, Heidelberg and Pisa, and received the M.D. degree in Be ...
, from whom he learned elements of physiological technique. Then in 1893, at age 27, he accepted the chairmanship of
pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
at the
University of Michigan , mottoeng = "Arts, Knowledge, Truth" , former_names = Catholepistemiad, or University of Michigania (1817–1821) , budget = $10.3 billion (2021) , endowment = $17 billion (2021)As o ...
, replacing the newly resigned Professor J. J. Abel. While there he taught, conducted research and wrote his ''Text-Book of Pharmacology'' and ''Therapeutics'', an unrivaled book for thirty years with a posthumous edition published in 1928. Cushny's contributions to the field of pharmacology were considerable. He performed, with the most modern techniques of the time, the first experimental analysis of the action of
digitalis ''Digitalis'' ( or ) is a genus of about 20 species of herbaceous perennial plants, shrubs, and biennials, commonly called foxgloves. ''Digitalis'' is native to Europe, western Asia, and northwestern Africa. The flowers are tubular in sha ...
on warm-blooded animals and explained its effects, thereby increasing the drug's therapeutic use and value. He was the first to understand the similarity between clinical and experimental auricular
fibrillation Fibrillation is the rapid, irregular, and unsynchronized contraction of muscle fibers. An important occurrence is with regard to the heart. Cardiology There are two major classes of cardiac fibrillation: atrial fibrillation and ventricular fib ...
. He was also interested for several years in the physiological action of optical isomers and, in 1900, the mechanisms of kidney secretion, providing three advanced papers on the subject between 1901 and 1904 in the ''Journal of Physiology''. In 1917 he presented the paper, ''The Secretion of Urine'', an advancement of the "modern theory" of kidney secretion, and also wrote a second edition of it released posthumously. Here he laid aside the theories of the inexplicable vital activities of the kidneys. He claimed that their primary structures, the
Glomeruli ''Glomerulus'' () is a common term used in anatomy to describe globular structures of entwined vessels, fibers, or neurons. ''Glomerulus'' is the diminutive of the Latin ''glomus'', meaning "ball of yarn". ''Glomerulus'' may refer to: * the filter ...
, simply filter out harmful bodily waste products while useful nutrients are reabsorbed into the body in the
renal tubule The nephron is the minute or microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structure ca ...
s. In 1905 he accepted the chair of pharmacology at
University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ...
(UCL), and then in 1918, replaced the chair vacated by Sir Thomas Fraser in Edinburgh, where remained until his death. In 1907 he was elected a Fellow of the
Royal Society of London The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
. In 1919 he was elected a Fellow of the
Royal Society of Edinburgh The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established i ...
, his proposers being Sir
Edward Albert Sharpey-Schafer Sir Edward Albert Sharpey-Schafer FRS FRSE FRCP LLD (2 June 1850 – 29 March 1935) was an English physiologist. He is regarded as a founder of endocrinology: in 1894 he discovered and demonstrated the existence of adrenaline together with G ...
, Sir James Walker,
John Horne John Horne PRSE FRS FRSE FEGS LLD (1 January 1848 – 30 May 1928) was a Scottish geologist. He served as President of the Royal Society of Edinburgh from 1915 to 1919. Life Horne was born on 1 January 1848, in Campsie, Stirlingshire, the ...
, and Arthur Robinson. Whilst in Edinburgh, he bought a historic manor house, the "Dumbiedykes" of the ''Heart of Midlothian'', that he retired to when entertaining international medical students and physicians. He was an avid
horticulturalist Horticulture is the branch of agriculture that deals with the art, science, technology, and business of plant cultivation. It includes the cultivation of fruits, vegetables, nuts, seeds, herbs, sprouts, mushrooms, algae, flowers, seaweeds and no ...
, spending more and more time in his garden. He married Sarah Firbank (1870-1928) in 1896. He died of a sudden apoplectic stroke at his home in
Edinburgh Edinburgh ( ; gd, Dùn Èideann ) is the capital city of Scotland and one of its 32 Council areas of Scotland, council areas. Historically part of the county of Midlothian (interchangeably Edinburghshire before 1921), it is located in Lothian ...
,
Scotland Scotland (, ) is a country that is part of the United Kingdom. Covering the northern third of the island of Great Britain, mainland Scotland has a border with England to the southeast and is otherwise surrounded by the Atlantic Ocean to the ...
on 25 February 1926. He is buried in Liberton Cemetery in south Edinburgh. The grave lies against the north wall of the southern cemetery (backing onto the more modern extension).


Notable monographic works

*''The Action and Uses in Medicine of Digitalis and Its Allies'' (1925) *''The Biological Relation of Optically Isometric Substances'' (1926) *''The Secretion of Urine'' (1917)


References

{{DEFAULTSORT:Cushy, Arthur Robertson People associated with Edinburgh Alumni of the University of Aberdeen University of Michigan faculty Academics of University College London British emigrants to the United States Academics of the University of Aberdeen Scottish physiologists Scottish pharmacologists Fellows of the Royal Society People from Moray 1866 births 1926 deaths